PinnedNo, You Won’t Make a Scientific Breakthrough with Yesterday’s Omics Analysis TechThe ultimate goal of omics data analysis is to identify every gene in human profiles and other organisms, and to match each gene with the protein it encodes and reveal the structure and function of each protein. Understanding these biological processes at the molecular level contributes to understanding metabolic pathways…Genetic Research5 min readGenetic Research5 min read
Jan 24What is precision medicine?In 1999, an innovative collaboration between 10 of the world’s largest pharmaceutical companies, the world’s largest medical research charity, and five leading academic centres emerged in the form of The SNP Consortium (TSC). Focused on advancing the field of medicine and development of genetic-based diagnostics and therapeutics, the TSC…Genetic Research6 min readGenetic Research6 min read
Jan 9Explained: how to plot the prediction quality metrics with AlphaFold2In a previous blog post , we discussed the importance of AlphaFold2 (as well as other, deep-learning based methods) to accelerate the process of drug discovery by predicting the 3-dimensional structure of proteins and protein complexes. LENS ai(IPA) provides a pipeline integrating the standard AlphaFold2 workflow, as well as additional…Biological Databases11 min readBiological Databases11 min read
Nov 28, 2022AI in Biopharma: Challenges and OpportunitiesThere are an estimated novemdecillion, or 10 60, molecules in the known universe with potential drug-like traits that could be developed into life-saving treatments. And then there is the sheer scale of data. Due to the volume of complex data, DNA sequencing data has been called the poster child of…NLP3 min readNLP3 min read
Oct 24, 2022Quality Control of RNA-seq DataDo not rush through the quality control step of your RNA sequencing (RNA-seq) data processing pipeline. It is really the data exploration part of whatever pipeline you are running — you will thank yourself later for taking the time to execute properly and thoroughly. At LENSai (IPA), quality control (QC)…Omics Data Analysis3 min readOmics Data Analysis3 min read
Oct 10, 2022AI, NLP and the ROI of drug developmentThis time-consuming and cost-intensive model of drug development has obvious price, affordability and accessibility implications. Combine this with the low productivity rate of drug development and you have a scenario where, as one study concluded , expected financial return ultimately determines which drugs are developed up to launch. This ROI-focused…AI4 min readAI4 min read
Sep 25, 2022Accelerating pharma R&D and innovation through technology partnershipsThe recent race to market for COVID-19 vaccines has only accentuated the value of alliances as companies with core vaccine capabilities turned to external partnerships to leverage the value of nascent mRNA technology. …Drug Development3 min readDrug Development3 min read
Sep 12, 2022Functional multiomics and antibody discoveryToday, omics refers to an array of technologies used to measure and functionally characterise different biological molecules in cells or tissues. These technologies collectively provide a comprehensive view of an individual’s genetic makeup that is critical to the development of personalised medicines. They drive the development of diagnostic and therapeutic…Multi Omic4 min readMulti Omic4 min read
Aug 16, 2022A Hybrid Approach to NLP in Drug DiscoveryHowever, NLP in drug discovery is not a monolithic concept. There are several possible approaches, each of which may be particularly suited for specific applications. Moreover, any comprehensive solution for integrated enterprise-wide analysis will likely require a blended or hybrid NLP approach. So here’s a quick dive into some of…NLP4 min readNLP4 min read
Aug 8, 2022AI in early phase drug developmentAI technologies are currently the most disruptive trend in the pharmaceutical industry. Over the past year, we have quite extensively covered the impact these intelligent technologies can have on conventional drug discovery and development processes. We charted how AI/ML technologies came to be a core component of drug discovery and…AI6 min readAI6 min read
