PinnedNo, You Won’t Make a Scientific Breakthrough with Yesterday’s Omics Analysis TechThe ultimate goal of omics data analysis is to identify every gene in human profiles and other organisms, and to match each gene with the protein it encodes and reveal the structure and function of each protein. Understanding these biological processes at the molecular level contributes to understanding metabolic pathways…Genetic Research5 min readGenetic Research5 min read
Mar 20Why we love multi-omics analysisThe first step in the transition to this holistic model is to catalog a complete of biological systems and decode how they connect, interact, and individually and collectively correlate to the function and behavior of that specific system. is the science of analyzing the structure and functions of all the…Omics Data Analysis4 min readOmics Data Analysis4 min read
Mar 6Key elements of successful AI-native drug discoveryThe use of AI in drug discovery has been progressively expanding over the past decade. Over the next decade, according to Morgan Stanley Research , even modest AI/ML-enabled improvements in early-stage drug development success rates could deliver an additional 50 novel therapies and create a $50 billion opportunity. AI-enabled drug…Precision Medicine5 min readPrecision Medicine5 min read
Feb 19What is a biomarker?A biomarker, or biological marker, broadly refers to a range of objectively, accurately, and reproducibly measurable medical signs . These signs indicate the medical state of a patient in terms of the presence/progress, or the effect of treatment on a particular disease. …Genetic Research4 min readGenetic Research4 min read
Feb 6Precision drugs for the precision medicine eraCurrently, chemotherapy, using cytotoxic small molecules to kill cancer cells, is the predominant conventional cancer treatment. Despite the clinical benefits of this approach, there are several factors, including low selectivity and high toxicity to normal cells, that limit its therapeutic efficacy. …Genetic Research3 min readGenetic Research3 min read
Jan 24What is precision medicine?In 1999, an innovative collaboration between 10 of the world’s largest pharmaceutical companies, the world’s largest medical research charity, and five leading academic centres emerged in the form of The SNP Consortium (TSC). Focused on advancing the field of medicine and development of genetic-based diagnostics and therapeutics, the TSC aims…Genetic Research6 min readGenetic Research6 min read
Jan 9Explained: how to plot the prediction quality metrics with AlphaFold2In a previous blog post , we discussed the importance of AlphaFold2 (as well as other, deep-learning based methods) to accelerate the process of drug discovery by predicting the 3-dimensional structure of proteins and protein complexes. LENS ai(IPA) provides a pipeline integrating the standard AlphaFold2 workflow, as well as additional…Biological Databases11 min readBiological Databases11 min read
Nov 28, 2022AI in Biopharma: Challenges and OpportunitiesThere are an estimated novemdecillion, or 10 60, molecules in the known universe with potential drug-like traits that could be developed into life-saving treatments. And then there is the sheer scale of data. Due to the volume of complex data, DNA sequencing data has been called the poster child of…NLP3 min readNLP3 min read
Oct 24, 2022Quality Control of RNA-seq DataDo not rush through the quality control step of your RNA sequencing (RNA-seq) data processing pipeline. It is really the data exploration part of whatever pipeline you are running — you will thank yourself later for taking the time to execute properly and thoroughly. At LENSai (IPA), quality control (QC)…Omics Data Analysis3 min readOmics Data Analysis3 min read
Oct 10, 2022AI, NLP and the ROI of drug developmentThis time-consuming and cost-intensive model of drug development has obvious price, affordability and accessibility implications. Combine this with the low productivity rate of drug development and you have a scenario where, as one study concluded , expected financial return ultimately determines which drugs are developed up to launch. This ROI-focused…AI4 min readAI4 min read
